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p53 (phospho Thr387) Antibody

p53 (phospho Thr387) Antibody p53 (phospho Thr387) Antibody

Instruction Manual!

Product name: p53 (phospho Thr387) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:IHC
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

p53 (phospho Thr387) Antibody

Catalog Number:IC287196

Product Profile

Product Name p53 (phospho Thr387) Antibody
Antibody Type Primary Antibodies
Productdescription
							
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.1) Zakut-Houri R., EMBO J. 4:1251-1255(1985).
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Immunogen
p53 (phospho Thr387) antibody was raised against a peptide sequence around phosphorylation site of threonine 387 (F-K-T (p)-E-G) derived from Human p53.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

IHC

Species Reactivity

Human

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol TP53
Alternative Names
TP53
tumor protein p53
Tumor suppressor p53
MolecularWeight(MW)  43 kDa
Tissue Specificity The antibody detects endogenous levels of p53 only when phosphorylated at threonine 387.

Database Links

Entrez Gene 7157
Protein Accession NP_000537.3

Application

  • Application

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Thr387) antibody (left) or the same antibody preincubated with blocking peptide (right).

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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