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p53 (phospho Ser6) Antibody

p53 (phospho Ser6) Antibody p53 (phospho Ser6) Antibody

Instruction Manual!

Product name: p53 (phospho Ser6) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:IHCWB
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

p53 (phospho Ser6) Antibody

Catalog Number:IC287195

Product Profile

Product Name p53 (phospho Ser6) Antibody
Antibody Type Primary Antibodies
Productdescription 
							
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.1) Lin T, et al. (2005) Nat Cell Biol; 7 (2): 165-71. Vega FM, et al. (2004) Mol Cell Biol; 24 (23): 10366-80. Li J, et al. (2004) J Biol Chem; 279 (40): 41275-9. Wang J, et al. (2004) J Biol Chem; 279 (38): 39584-92.
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Immunogen
p53 (Phospho-Ser6) antibody was raised against a peptide sequence around phosphorylation site of serine 6 (P-Q-S (p) -D-P) derived from Human p53.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

IHCWB

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
Species Reactivity

HumanMouse

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol TP53
Alternative Names
P53
BCC7
LFS1
TRP53
CHK1
Antigen NY-CO-13
Phosphoprotein p53
TP53
Tumor suppressor p53
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MolecularWeight(MW)  53 kDa
Tissue Specificity This antibody detects endogenous level of p53 only when phosphorylated at serine 6.

Database Links

Entrez Gene 7157
Protein Accession NP_000537.3

Application

  • Application

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Ser6).

  • Application

    Western blot analysis of lysed extracts from HT29 and HeLa cells untreated or treated with UV using p53 (Phospho-Ser6).

Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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