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Tau (phospho Thr205) Antibody

Tau (phospho Thr205) Antibody Tau (phospho Thr205) Antibody

Instruction Manual!

Product name: Tau (phospho Thr205) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:IHCWB
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

Tau (phospho Thr205) Antibody

Catalog Number:IC292866

Product Profile

Product Name Tau (phospho Thr205) Antibody
Antibody Type Primary Antibodies
Productdescription 
							
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.1) del C Alonso A, et al. (2004) J Biol Chem; 279 (33): 34873-81Li G, Yin H, Kuret J (2004) J Biol Chem; 279 (16): 15938-45Giasson BI, et al. (2002) Biochemistry; 41 (51): 15376-87Liu F, et al. (2002) FEBS Lett; 530 (1-3): 209Taniguchi T, et al. (2001) J Biol Chem; 276 (13): 10025-31
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Immunogen
Tau (Phospho-Thr205) antibody was raised against a peptide sequence around phosphorylation site of threonine 205 (P-G-T (p) -P-G) derived from Human Tau.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

IHCWB

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol MAPT
Alternative Names
TAU
MSTD
PPND
DDPAC
MAPTL
MTBT1
MTBT2
FTDP-17
CREB2
CREBP1
MAPT
MTAPT
Neurofibrillary tangle protein
PHF-tau
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MolecularWeight(MW)  48, 62, 78 kDa
Tissue Specificity This antibody detects endogenous level of Tau only when phosphorylated at threonine 205.

Database Links

Entrez Gene 4137
Protein Accession NP_001116538.1

Application

  • Application

    Western blot analysis of lysed extracts from mouse brain tissue using Tau (Phospho-Thr205).

  • Application

    Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer’s Disease using Tau (Phospho-Thr205).

Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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