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FAK (phospho Tyr576) Antibody

FAK (phospho Tyr576) Antibody FAK (phospho Tyr576) Antibody

Instruction Manual!

Product name: FAK (phospho Tyr576) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:WB
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

FAK (phospho Tyr576) Antibody

Catalog Number:IC278449

Product Profile

Product Name FAK (phospho Tyr576) Antibody
Antibody Type Primary Antibodies
Productdescription
							
							
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.1) Tong L, et al. (2013)Biochim Biophys Acta 1833, 1304-15. Chen S, et al. (2013)Sci Signal 6, ra40. Tian H, et al. (2012)EMBO J 31, 3885-900.
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Immunogen
FAK (phospho Tyr576) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine576 (S-T-Y (p)-Y-K) derived from Human FAK.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB

Western Blot: 1:500~1:1000:
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol PTK2
Alternative Names
FADK 1
FAK1
Focal adhesion kinase 1
PTK2
pp125FAK
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Molecular Weight(MW) 125 kDa
Tissue Specificity The antibody detects endogenous level of FAK only when phosphorylated at tyrosine 576.

Database Links

Entrez Gene 5747
Protein Accession NP_001186578.1

Application

  • Application

    Western blot analysis of extracts from NIH-3T3 tissue using FAK (Phospho-Tyr576) Antibody. The lane on the right is treated with the antigen-specific peptide.

Application Notes
Western Blot: 1:500~1:1000:

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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