elisa kit elisa kits logo

Tel:631-424-0089
Fax:631-424-0095
Email: info@immunoclone.com

Home>>Products >>  New Products

Rb Antibody

Rb Antibody Rb Antibody

Instruction Manual!

Product name: Rb Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:IHC
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

Rb Antibody

Catalog Number:IC289583

Product Profile

Product Name Rb Antibody
Antibody Type Primary Antibodies
Productdescription
							
							
Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.1) Roesch A, et al. (2005) Mod Pathol. 18 (4): 565-572. Huang H, et al. (2004) Oncogene. 23 (12): 2161-2176. Kitagawa M, et al. (1996) EMBO J. 15 (24): 7060-7069.
More 
Immunogen
Rb (Ab-780) antibody was raised against a peptide sequence around aa. 778~782 (T-L-S-P-I) derived from Human Rb.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

IHC

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
Species Reactivity

MouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol RB1
Alternative Names
RB
pRb
OSRC
pp110
p105-Rb
Gabra-3
More 
Molecular Weight(MW) 110 kDa
Tissue Specificity This antibody detects endogenous level of taotal Rb protein.

Database Links

Entrez Gene 5925
Protein Accession NP_000312.2

Application

  • Application

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Rb (Ab-780).

Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

Copyright @ USA Immuno Clone Co., Ltd(I&C) All Rights Reserved Language:Chinese