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p70 S6 Kinase (phospho Ser411) Antibody

p70 S6 Kinase (phospho Ser411) Antibody p70 S6 Kinase (phospho Ser411) Antibody

Instruction Manual!

Product name: p70 S6 Kinase (phospho Ser411) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:WB
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

p70 S6 Kinase (phospho Ser411) Antibody

Catalog Number:IC287213

Product Profile

Product Name p70 S6 Kinase (phospho Ser411) Antibody
Antibody Type Primary Antibodies
Productdescription 
							
Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.1) Satoru Eguchi et al. (1999) J Biol Chem, Vol. 274: 36843-36851Papst PJ, et al. (1998) J Biol Chem. 273 (24): 15077-84. Ulrike Krause et al. (2002) Eur. J. Biochem. 269: 3751-3759 cLe, X. F, et al. (2003) Oncogene 22: 484–97
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Immunogen
p70 S6 Kinase (Phospho-Ser411) antibody was raised against a peptide sequence around phosphorylation site of serine 411 (I-R-S (p) -P-R) derived from Human p70 S6 Kinase.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Species Reactivity

Human

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol RPS6KB1
Alternative Names
S6K
PS6K
S6K1
STK14A
p70-S6K
p70S6KA
p70-alpha
S6K-beta-1
p70(S6K)-alpha
MACS
PRKCSL
KS6B1
P70-S6K
RPS6KB1
S6K
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MolecularWeight(MW)  70 85 kDa
Tissue Specificity This antibody detects endogenous level of p70 S6 Kinase only when phosphorylated at serine 411.

Database Links

Entrez Gene 6198
Protein Accession NP_003152.1

Application

  • Application

    Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase (Phospho-Ser411). Bottom Image: Immunofluorescence staining of methanol-fixed MCF7 cells using p70 S6 Kinase (Phospho-Ser411).

  • Application

    Western blot analysis of lysed extracts from MCF cells untreated or treated with EGF using p70 S6 Kinase (Phospho-Ser411).

ApplicationNotes 
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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