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NFkB p105 / p50 Antibody

NFkB p105 / p50 Antibody

Instruction Manual!

Product name:	NFkB p105 / p50 Antibody
Source:	Rabbit
Purity:	>95%
Buffer Formulation:	Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:	IHCWB
Storage:	Store antibody at -20˚C for up to one year.
UOM:	100ug

NFkB p105 / p50 Antibody

Catalog Number：IC286116

Product Profile

Product Name	NFkB p105 / p50 Antibody
Antibody Type	Primary Antibodies
Productdescription	NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.1) Soren Beinke et al. (2004) Biochem J. 382 (Pt 2): 393–409. Vigo Heissmeyer1, et al. (1999) The EMBO Journal 18: 4766–4778, F Chen, et al. (2006) Cell Death and Differentiation 13: 1835–1838. Kris A. Steinbrecher, et al. (2005) Mol Cell Biol. 25 (19): 8444–8455. More
Immunogen	NFkB-p105/p50 (Ab-932) antibody was raised against a peptide sequence around aa.930~934 (E-T-S-F-R) derived from Human NFκB-p105.

Key Feature

Clonality	Polyclonal
Host Species	Rabbit
Tested Applications	IHCWB
	Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Affinity purified

Target Information

Gene Symbol	NFKB1
Alternative Names	p50 KBF1 p105 EBP-1 NF-kB1 NFKB-p50 NFkappaB NF-kappaB NFKB-p105 NF-kappa-B PRMT4 DNA-binding factor KBF1 NF-kappa-B1 p84/NF-kappa-B1 p98 NFKB1 NFkB-p50 More
Molecular Weight(MW)	50, 120 kDa
Tissue Specificity	This antibody detects endogenous level of total NFκB-p105/p50 protein.

Database Links

Entrez Gene	4790
Protein Accession	NP_001158884.1

Application

Application

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFκB-p105/p50 (Ab-932).
Application

Western blot analysis of lysed extracts from HeLa cells using NFκB-p105/p50 (Ab-932).

Application Notes	Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:

Additional Information

Form	Liquid
StorageInstructions	Store antibody at -20˚C for up to one year.
Storage Buffer	Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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