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IRS 1 (phospho Ser639) Antibody

IRS 1 (phospho Ser639) Antibody IRS 1 (phospho Ser639) Antibody

Instruction Manual!

Product name: IRS 1 (phospho Ser639) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:IHCWB
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

IRS 1 (phospho Ser639) Antibody

Catalog Number:IC282338

Product Profile

Product Name IRS 1 (phospho Ser639) Antibody
Antibody Type Primary Antibodies
Productdescription
							
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit1) Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8): 4640-4645Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1): 63-76Steppan CM, et al. (2005) Mol Cell Biol; 25 (4): 1569-1575Batty IH, et al. (2004) Biochem J; 379 (Pt 3): 641-651
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Immunogen
IRS-1 (Phospho-Ser639) antibody was raised against a peptide sequence around phosphorylation site of serine 639 (P-K-S (p) -V-S) derived from Human IRS-1.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

IHCWB

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol IRS1
Alternative Names
HIRS-1
NFKB3
IRS-1
IRS1
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Molecular Weight(MW) 180 kDa
Tissue Specificity This antibody detects endogenous level of IRS-1 only when phosphorylated at serine 639.

Database Links

Entrez Gene 3667
Protein Accession NP_005535.1

Application

  • Application

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IRS-1 (Phospho-Ser639).

  • Application

    Western blot analysis of lysed extracts from 293 cells untreated or treated with serum using IRS-1 (Phospho-Ser639).

Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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