KIT encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Somatic gain-of-function mutations in the extracellular domain, kinase domains 1 and 2 are found in gastrointestinal stromal tumors (GISTs). Mutations in c-KIT gene are also associated with mast cell disease, acute myelogenous lukemia, and piebaldism. Tyrosine kinase inhibitor STI571 has been shown to inhibit GIST cells that express mutated c-KIT.
							
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IHC

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