Progesterone Receptor Antibody

Catalog Number：IC288885

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Product Profile

Product Name	Progesterone Receptor Antibody
Antibody Type	Primary Antibodies
Productdescription	Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition, progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.1) Narayanan R, et al. (2005) Mol Cell Biol; 25 (8): 2885-98. Knotts TA, et al. (2001) J Biol Chem; 276 (11): 8475-83. Clemm DL, et al. (2000) Mol Endocrinol; 14 (1): 52-65. Zhang Y, et al. (1997) Mol Endocrinol; 11 (6): 823-32 More
Immunogen	Progesterone Receptor (Ab-190) antibody was raised against a peptide sequence around aa.188~192 (G-L-S-P-A) derived from Human Progesterone Receptor.

Key Feature

Clonality	Polyclonal
Host Species	Rabbit
Tested Applications	IFWB
	Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Affinity purified

Target Information

Gene Symbol	PGR
Alternative Names	PR NR3C3 P53 PGR PRGR More
Molecular Weight(MW)	99 kDa
Tissue Specificity	This antibody detects endogenous level of total Progesterone Receptor protein.

Database Links

Entrez Gene	5241
Protein Accession	NP_000917.3

Application

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  Application

  Immunofluorescence staining of methanol-fixed HeLa cells using Progesterone Receptor (Ab-190).

Application Notes	Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:

Additional Information

Form	Liquid
StorageInstructions	Store antibody at -20˚C for up to one year.
Storage Buffer	Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.