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P38 MAPK (phospho Tyr182) Antibody

P38 MAPK (phospho Tyr182) Antibody P38 MAPK (phospho Tyr182) Antibody

Instruction Manual!

Product name: P38 MAPK (phospho Tyr182) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:IHCWB
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

P38 MAPK (phospho Tyr182) Antibody

Catalog Number:ic287169

Product Profile

Product Name P38 MAPK (phospho Tyr182) Antibody
Antibody Type Primary Antibodies
Productdescription 
							
Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.1) Ming Zheng, et al. (2005) The FASEB Journal. 19: 109-111Bernt van den et al. (2001) Blink Immunology, 166: 582-587Arshad Rahman, et al. (2004) Am J Physiol Lung Cell Mol Physiol 287: L1017-L1024Osamu Yoshino, et al. (2003) Endocrinology & Metabolism Vol. 88: 2236-2241
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Immunogen
P38 MAPK (Phospho-Tyr182) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 182 (T-G-Y (p) -V-A) derived from Human P38 MAPK.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

IHCWB

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol MAPK14
Alternative Names
RK
p38
CSBP
EXIP
Mxi2
CSBP1
CSBP2
CSPB1
PRKM14
PRKM15
SAPK2A
p38ALPHA
FLK1
VEGFR2
MAPK2
MAPKAPK-2
MAPKAPK2
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MolecularWeight(MW)  43 kDa
Tissue Specificity This antibody detects endogenous level of P38MAPK only when phosphorylated at tyrosine 182.

Database Links

Entrez Gene 1432
Protein Accession NP_001306.1

Application

  • Application

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using P38 MAPK (Phospho-Tyr182).

  • Application

    Western blot analysis of lysed extracts from HeLa cells untreated or treated with UV for the indicated times, using P38 MAPK (Phospho-Tyr182).

Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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