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IGF1R (phospho Tyr1346) Antibody

IGF1R (phospho Tyr1346) Antibody IGF1R (phospho Tyr1346) Antibody

Instruction Manual!

Product name: IGF1R (phospho Tyr1346) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:IHC
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

IGF1R (phospho Tyr1346) Antibody

Catalog Number:IC281721

Product Profile

Product Name IGF1R (phospho Tyr1346) Antibody
Antibody Type Primary Antibodies
Productdescription 
							
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.1) Ullrich A., EMBO J. 5:2503-2512(1986).
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Immunogen
IGF1R (phospho Tyr1346) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1346 (Q-P-Y (p)-A-H) derived from Human IGF1R .

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

IHC

Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol IGF1R
Alternative Names
CD221
kinase IGF1R
IGF1R
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MolecularWeight(MW)  154 kDa
Tissue Specificity The antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 1346.

Database Links

Entrez Gene 3480
Protein Accession NP_000866.1

Application

  • Application

    Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF1R (Phospho-Tyr1346) antibody (left) or the same antibody preincubated with blocking peptide (right).

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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