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Amyloid Precursor Protein Antibody

Amyloid Precursor Protein Antibody Amyloid Precursor Protein Antibody

Instruction Manual!

Product name: Amyloid Precursor Protein Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Applications:WB
Storage:Amyloid Precursor Protein antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
UOM:100ug

Amyloid Precursor Protein Antibody

Catalog Number:IC271045

Product Profile

Product Name Amyloid Precursor Protein Antibody
Antibody Type Primary Antibodies
Productdescription 
							
A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003). The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).1) Ando K, Iijima KI, Elliott JI, Kirino Y, Suzuki T (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem 276:40353-40361.
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Immunogen
Peptide corresponding to amino acid residues from the C-terminal region of rat APP.

Key Feature

Clonality Polyclonal
Host Species Rabbit
TestedApplications

 WB

The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with canine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Species Reactivity

DogHumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol App
Alternative Names
Abeta
ABPP
APP
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Molecular Weight(MW) 115

Database Links

Entrez Gene 54226
Protein Accession P08592

Application

  • Application

    Western blot of rat hippocampal lysate showing specific immunolabeling of the ~115k APP protein.

Application Notes
The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with canine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Additional Information

Form Liquid
StorageInstructions  Amyloid Precursor Protein antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Storage Buffer 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.

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