CD45.2 Antibody

Instruction Manual!

Product name:	CD45.2 Antibody
Source:	Rabbit
Purity:	>95%
Buffer Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Applications:	FACSICCIHCIP
Storage:	The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.
UOM:	100ug

CD45.2 Antibody

Catalog Number：IC274685

Product Profile

Product Name	CD45.2 Antibody
Antibody Type	Primary Antibodies
Productdescription	The 104 monoclonal antibody specifically reacts with the mouse CD45 molecule, the Leukocyte Common Antigen (LCA) which occurs in the alloantigen CD45.2-expressing mouse strains (C57BL/6, CBA, 129, A, AKR, C58, DBA/1, DBA/2, BALB/c, and C3H/He). The 104 monoclonal antibody does not react with the leukocytes of the CD45.1-expressing mouse strains (DA, SJL/J, RIII, and STS/A). The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction. The 104 antibody inhibits some of the B lymphocytes responses, reduces the serum IgG levels, and influences the autoimmune renal pathology.1) Shen, F. W., Tung, J. S., Boyse, E. A. (1986). Further definition of the Ly-5 system.Immunogenetics,24(3), 146-149. More

Product Name

CD45.2 Antibody

Antibody Type

Primary Antibodies

Productdescription

							
								The 104 monoclonal antibody specifically reacts with the mouse CD45 molecule, the Leukocyte Common Antigen (LCA) which occurs in the alloantigen CD45.2-expressing mouse strains (C57BL/6, CBA, 129, A, AKR, C58, DBA/1, DBA/2, BALB/c, and C3H/He). The 104 monoclonal antibody does not react with the leukocytes of the CD45.1-expressing mouse strains (DA, SJL/J, RIII, and STS/A). The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction. The 104 antibody inhibits some of the B lymphocytes responses, reduces the serum IgG levels, and influences the autoimmune renal pathology.1) Shen, F. W., Tung, J. S., Boyse, E. A. (1986). Further definition of the Ly-5 system.Immunogenetics,24(3), 146-149.
							
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Key Feature

Clonality	Monoclonal
Isotype	IgG2a,k
Host Species	Mouse
Tested Applications	FACSICCIHCIP
Species Reactivity	Mouse
Concentration	1mg/ml
Purification	Affinity purified

Target Information

Gene Symbol	Ptprc
AlternativeNames	loc B220 Cd45 L-CA Ly-5 T200 CD45R Lyt-4 Ptprc More
Tissue Specificity	The 104 monoclonal antibody specifically reacts with the mouse CD45 molecule, the Leukocyte Common Antigen (LCA) which occurs in the alloantigen CD45.2-expressing mouse strains (C57BL/6, CBA, 129, A, AKR, C58, DBA/1, DBA/2, BALB/c, and C3H/He).

Database Links

Entrez Gene	19264

Application

Additional Information

Form	Liquid
StorageInstructions	The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.
Storage Buffer	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.