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ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody

ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody

Instruction Manual!

Product name: ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:IFIHCWB
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody

Catalog Number:IC269639

Product Profile

Product Name ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody
Antibody Type Primary Antibodies
Productdescription 
							
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.1) Wang, J. Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N. N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B. B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259.
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Immunogen
ABL1/2 (phospho-Tyr393/429) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 393/429 (D-T-Y (p) -T-A) derived from Human ABL1/2.

Key Feature

Clonality Polyclonal
Host Species Rabbit
TestedApplications 

IFIHCWB

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
Species Reactivity

HumanMouse

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol ABL1 ABL2
Alternative Names
ABL
JTK7
p150
c-ABL
v-abl
c-ABL1
bcr/abl
BHLHE39
Abelson murine leukemia viral oncogene homolog 1
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MolecularWeight(MW)  210 kDa
Tissue Specificity This antibody detects endogenous level of ABL1/2 only when phosphorylated at tyrosine393/429.

Database Links

Entrez Gene 25 / 27
Protein Accession NP_005148.2 / NP_001129472.1

Application

  • Application

    Western blot analysis of lysed extracts from HL60 cells using ABL1/2 (phospho-Tyr393/429).

  • Application

    Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ABL1/2 (Phospho-Tyr393/429). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using ABL1/2 (phospho-Tyr393/429).

ApplicationNotes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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