elisa kit elisa kits logo

Tel:631-424-0089
Fax:631-424-0095
Email: info@immunoclone.com

Home>>Products >>  New Products

IRF8 Antibody

IRF8 Antibody IRF8 Antibody

Instruction Manual!

Product name: IRF8 Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:IRF8 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications:ELISAIFWB
Storage:IRF8 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
UOM:100ug

IRF8 Antibody

Catalog Number:IC282323

Product Profile

Product Name IRF8 Antibody
Antibody Type Primary Antibodies
Productdescription 
							
IRF8 Antibody: Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases, but IRF8 mediates activation of NF-κB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.1) Malmgaard L. Induction and regulation of IFNs during viral infections. J. Interferon & Cyto. Res. 2004; 24:439-54
More 
Immunogen
IRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IRF8. The immunogen is located within the last 50 amino acids of IRF8.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
TestedApplications 

ELISAIFWB

IRF8 antibody can be used for detection of IRF8 by Western blot at 1 μg/mL. For immunofluorescence start at 10 μg/mL.:
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol IRF3
Alternative Names
IRF8 Antibody: Interferon regulatory factor 3
IRF-3
Sequence Similarities 2) Cat. No. 17-004 - K-562 Cell Slide

Database Links

Entrez Gene 3661
Protein Accession NP_002154

Application

  • Application

    Immunofluorescence of IRF8 in K562 cells with IRF8 antibody at 10 μg/mL.

  • Application

    Western blot analysis of IRF8 in human thymus tissue lysate with IRF8 antibody at 1μg/mL in (A) the presence and (B) absence of blocking peptide.

PositiveControl 1) Cat. No. 1314 - Human Thymus Tissue Lysate
ApplicationNotes
IRF8 antibody can be used for detection of IRF8 by Western blot at 1 μg/mL. For immunofluorescence start at 10 μg/mL.:

Additional Information

Form Liquid
StorageInstructions  IRF8 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer IRF8 Antibody is supplied in PBS containing 0.02% sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

Copyright @ USA Immuno Clone Co., Ltd(I&C) All Rights Reserved Language:Chinese