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CASP3 antibody - C-terminal region
Instruction Manual!
| Product name: | CASP3 antibody - C-terminal region |
| Source: | Rabbit |
| Purity: | >95% |
| Buffer Formulation: | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Applications: | WBIHC |
| Storage: | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| UOM: | 100ug |
Rabbit anti-CASP3 polyclonal antibody - C-terminal region
Catalog Number：IC117853
Product Profile
| ProductName | Rabbit anti-CASP3 polyclonal antibody - C-terminal region |
|---|---|
| AntibodyType | Primary Antibodies |
| Immunogen |
The immunogen for anti-CASP3 antibody: synthetic peptide directed towards the C terminal of human CASP3 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | |
| Species Reactivity | |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | CASP3 |
|---|---|
| Gene Synonyms |
CPP32
More
CPP32B SCA-1 |
| Gene Full Name | Caspase 3, apoptosis-related cysteine peptidase |
| Gene Summary |
CASP3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
More
|
| Alternative Names |
CPP32
More
CPP32B SCA-1 |
| MolecularWeight(MW) | 12kDa |
| Sequence | 277 amino acids |
Database Links
| Entrez Gene | 836 |
|---|---|
| SwissProt ID | P42574 |
| Protein Accession | NP_116786 |
Application
-
Western blot
0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: THP-1 cell lysate -
Immunofluorescence
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
