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Elf3 antibody - middle region
Instruction Manual!
| Product name: | Elf3 antibody - middle region |
| Source: | Rabbit |
| Purity: | >95% |
| Buffer Formulation: | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Applications: | WB |
| Storage: | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| UOM: | 100ug |
Rabbit anti-Elf3 polyclonal antibody - middle region
Catalog Number：IC105434
Product Profile
| ProductName | Rabbit anti-Elf3 polyclonal antibody - middle region |
|---|---|
| AntibodyType | Primary Antibodies |
| Immunogen |
The immunogen for anti-Elf3 antibody: synthetic peptide directed towards the middle region of human Elf3 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | |
| Species Reactivity | |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | Elf3 |
|---|---|
| Gene Synonyms |
EPR-1
More
ERT ESE-1 ESX |
| Gene Full Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
| Gene Summary |
ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.
More
|
| Alternative Names |
EPR-1
More
ERT ESE-1 ESX |
| MolecularWeight(MW) | 41kDa |
| Sequence | 371 amino acids |
Database Links
| Entrez Gene | 1999 |
|---|---|
| SwissProt ID | P78545 |
| Protein Accession | NP_004424 |
Application
-
Western blot
0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: MCF7 cell lysate
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
