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NCOA3 Antibody
Instruction Manual!
| Product name: | NCOA3 Antibody |
| Source: | Mouse |
| Purity: | >95% |
| Buffer Formulation: | Purified recombinant fragment of NCOA3(aa1-200) expressed in E. Coli |
| Applications: | WB |
| Storage: | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| UOM: | 100ug |
NCOA3 Antibody
Catalog Number：IC215065
Product Profile
| Product Name | NCOA3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
Key Feature
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 2C11B12 |
| Host Species | Mouse |
| Tested Applications | |
|
WB~~1:500 - 2000.:
|
|
| Species Reactivity | |
| Concentration | 1mg/ml |
| Purification |
Target Information
| Gene Synonyms |
AIB1
More
BHLHE42 RAC3 TRAM1 |
|---|---|
| Alternative Names |
ACTR
AIB1 |
| MolecularWeight(MW) | 155293 Da |
| Function |
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9
More
|
| Tissue Specificity | Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney |
| Cellular Localization | Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus |
Database Links
| Entrez Gene | 8202 |
|---|---|
| Nucleotide Accession | NP_858045.1 |
Application
-
Application
Figure 1: Western blot analysis using anti-NCOA3 monoclonal antibody against truncated Trx-NCOA3 recombinant protein(1) and truncated NCOA3(aa1-200)-hIgGFc transfected CHOK1 cell lysate (2).
| Application Notes |
WB~~1:500 - 2000.:
|
|---|
Additional Information
| Form | Liquid |
|---|---|
| StorageInstructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of NCOA3(aa1-200) expressed in E. Coli. |
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
