Recombinant Human A Disintegrin and Metalloproteinase Domain 10

Instruction Manual!

Product name:	Recombinant Human A Disintegrin and Metalloproteinase Domain 10
Source:
Purity:
Buffer Formulation:	The ADAM10 solution contains 20mM Tris (pH 8), 1mM EDTA and 50% Glycerol. Sterile Filtered colorless solution.
Applications:
Storage:	Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
UOM:	10ug/50ug/100ug/200ug/1mg

Product Name A Disintegrin and Metalloproteinase Domain 10 (ADAM10), Recombinant Protein
Also Known As Recombinant Human A Disintegrin and Metalloproteinase Domain 10
Product Synonym Names ADAM10 Human; A Disintegrin and Metalloproteinase Domain 10 Human Recombinant; Kuz; AD10; MADM; CD156c; HsT18717; ADAM metallopeptidase domain 10; A disintegrin and metalloproteinase domain 10; Mammalian disintegrin-metalloprotease; Kuzbanian protein homolog; CDw156; ADAM 10; ADAM10
Product Gene Name ADAM10 recombinant protein [Similar Products]
Research Use Only For Research Use Only. Not for use in diagnostic procedures.

OMIM    602192

3D Structure    ModBase 3D Structure for O14672

Host    E Coli

Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.

Form/Format    The ADAM10 solution contains 20mM Tris (pH 8), 1mM EDTA and 50% Glycerol.
Sterile Filtered colorless solution.

Other Notes    Small volumes of ADAM10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Product Description specifically for ADAM10 recombinant protein
   Description: ADAM10 extracellular domain minus the signal peptide and pro-sequence Human Recombinant fused to N-terminal His-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 459 amino acids (214-672) and having a molecular mass of 55.089kDa.
Introduction: ADAM10 is part of the ADAM family which are cell surface proteins with a distinctive structure possessing both potential adhesion and protease domains. ADAM10 cleaves many proteins including TNF-alpha and E-cadherin. ADAM10 cleaves the membrane-bound precursor of tnf-alpha at 76- ala-|-val-77 to its mature soluble form. ADAM10 is in charge for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-a2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein ADAM10 is involved in the normal cleavage of the cellular prion protein. ADAM10 is involved in the cleavage of the adhesion molecule l1 at the cell surface and in the release of membrane vesicles, suggesting a vesicle-based protease activity. ADAM10 controls the proteolytic processing of notch and mediates lateral inhibition during neurogenesis.

Product Categories/Family forADAM10 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; A Disintegrin and Metalloproteinase Domain

NCBI/Uniprot data below describe general gene information for ADAM10. It may not necessarily be applicable to this product.

OMIM		602192
3D Structure		ModBase 3D Structure for O14672

Host		E Coli

Purity/Purification		Greater than 95.0% as determined by SDS-PAGE.
Form/Format		The ADAM10 solution contains 20mM Tris (pH 8), 1mM EDTA and 50% Glycerol. Sterile Filtered colorless solution.


Other Notes		Small volumes of ADAM10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Product Description specifically for ADAM10 recombinant protein		Description: ADAM10 extracellular domain minus the signal peptide and pro-sequence Human Recombinant fused to N-terminal His-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 459 amino acids (214-672) and having a molecular mass of 55.089kDa. Introduction: ADAM10 is part of the ADAM family which are cell surface proteins with a distinctive structure possessing both potential adhesion and protease domains. ADAM10 cleaves many proteins including TNF-alpha and E-cadherin. ADAM10 cleaves the membrane-bound precursor of tnf-alpha at 76- ala-\|-val-77 to its mature soluble form. ADAM10 is in charge for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-a2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein ADAM10 is involved in the normal cleavage of the cellular prion protein. ADAM10 is involved in the cleavage of the adhesion molecule l1 at the cell surface and in the release of membrane vesicles, suggesting a vesicle-based protease activity. ADAM10 controls the proteolytic processing of notch and mediates lateral inhibition during neurogenesis.
Product Categories/Family forADAM10 recombinant protein		RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; A Disintegrin and Metalloproteinase Domain

*NCBI/Uniprot data below describe general gene information for ADAM10. It may not necessarily be applicable to this product.*