Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S Isoform

Instruction Manual!

Product name:	Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S Isoform
Source:
Purity:
Buffer Formulation:	The ADAM12 solution contains 20mM Tris-HCl and 50% Glycerol. Sterile Filtered colorless solution.
Applications:
Storage:	Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
UOM:	10ug/50ug/100ug/200ug/1mg

Product Name A Disintegrin and Metalloproteinase Domain 12 S Isoform (ADAM12), Recombinant Protein
Also Known As Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S Isoform
Product Synonym Names ADAM12 Human; A Disintegrin and Metalloproteinase Domain 12 S-Isoform Human Recombinant; Meltrin alpha; MCMP; MLTN; MLTNA; MCMPMltna; ADAM metallopeptidase domain 12; ADAM 12; ADAM12
Product Gene Name ADAM12 recombinant protein [Similar Products]
Research Use Only For Research Use Only. Not for use in diagnostic procedures.

OMIM    602714

3D Structure    ModBase 3D Structure for O43184

Host    E Coli

Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.

Form/Format    The ADAM12 solution contains 20mM Tris-HCl and 50% Glycerol.
Sterile Filtered colorless solution.

Concentration    0.126 mg/ml (lot specific)

Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Other Notes    Small volumes of ADAM12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Product Description specifically for ADAM12 recombinant protein
   Description: ADAM12 Short/soluble isoform Human Recombinant fused to N-terminal His-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 531 amino acids (208-738) and having a molecular mass of 62 kDa.
Introduction: ADAM12 is part of the A Disintegrin and Metalloprotease protein family wjich are membrane-anchored proteins structurally related to snake venom disintegrins, and are involved in a range of biological processes concerning cell-cell and cell-matrix interactions, including fertilization, muscle development, and eurogenesis. ADAM12 has 2 alternatively spliced transcripts, a shorter/soluble secreted form called S-isoform and a longer membrane-bound form call L isoform. The S isoform is found to stimulate myogenesis. The short & soluble isoform lacks the transmembrane and cytoplasmic domains. ADAM12 S Isoform expression is limited to the placenta, embryo and foetus although levels have been detected in some tumour cell lines. ADAM12 takes part in skeletal muscle regeneration, specifically at the onset of cell fusion. ADAM12 is involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (by similarity).

Product Categories/Family forADAM12 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; A Disintegrin and Metalloproteinase Domain

OMIM		602714
3D Structure		ModBase 3D Structure for O43184

Host		E Coli

Purity/Purification		Greater than 95.0% as determined by SDS-PAGE.
Form/Format		The ADAM12 solution contains 20mM Tris-HCl and 50% Glycerol. Sterile Filtered colorless solution.
Concentration		0.126 mg/ml (lot specific)


Preparation and Storage		Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Other Notes		Small volumes of ADAM12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Product Description specifically for ADAM12 recombinant protein		Description: ADAM12 Short/soluble isoform Human Recombinant fused to N-terminal His-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 531 amino acids (208-738) and having a molecular mass of 62 kDa. Introduction: ADAM12 is part of the A Disintegrin and Metalloprotease protein family wjich are membrane-anchored proteins structurally related to snake venom disintegrins, and are involved in a range of biological processes concerning cell-cell and cell-matrix interactions, including fertilization, muscle development, and eurogenesis. ADAM12 has 2 alternatively spliced transcripts, a shorter/soluble secreted form called S-isoform and a longer membrane-bound form call L isoform. The S isoform is found to stimulate myogenesis. The short & soluble isoform lacks the transmembrane and cytoplasmic domains. ADAM12 S Isoform expression is limited to the placenta, embryo and foetus although levels have been detected in some tumour cell lines. ADAM12 takes part in skeletal muscle regeneration, specifically at the onset of cell fusion. ADAM12 is involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (by similarity).
Product Categories/Family forADAM12 recombinant protein		RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; A Disintegrin and Metalloproteinase Domain